Name: 17-Hydroxyventuricidin A
Brand: Biolinks K.K.
SKU: BLK-0960

For Research Use Only. Not for human or veterinary use.

17-Hydroxyventuricidin A (CAS: 113204-43-6) Product ID: BLK-0960 CAS 113204-43-6 Mechanism ATP synthase inhibitor Primary Target Mitochondrial F0F1-ATP synthase Pathway Oxidative phosphorylation; ATP synthesis
Structure
CAS	113204-43-6
Molecular Formula	C41H67NO12
Molecular Weight	765.99
Price	1mg: USD 150.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
Source Organism	Streptomyces sp.
Summary	17-Hydroxyventuricidin A is a macrolide antibiotic isolated from Streptomyces sp. with antifungal and antibacterial activity.
Details	17-Hydroxyventuricidin A is a macrolide antibiotic produced by Streptomyces sp. strain US80, isolated from Tunisian oasis soil. It was purified alongside irumamycin and X-14952B and structurally characterized using IR, ESI-MS, and 1H/13C NMR analyses. As a member of the venturicidin family, it is structurally related to venturicidin A, a known inhibitor of mitochondrial F0F1-ATP synthase. The compound exhibits antifungal and antibacterial activities, and its production is influenced by carbon source (glucose) and magnesium concentration. Production can be significantly enhanced (~70%) by addition of heat-killed fungi to the culture medium, suggesting elicitor-induced secondary metabolism. Due to its antifungal potency, it has potential applications in agricultural biocontrol strategies.
Browse Related	Mechanism ATP synthase inhibitor Open full index Primary Target Mitochondrial F0F1-ATP synthase Open full index Pathway Oxidative phosphorylation; ATP synthesis Open full index Chemical Class Macrolide (venturicidin family) Open full index
Mechanism	ATP synthase inhibitor
Primary Target	Mitochondrial F0F1-ATP synthase
Pathway	Oxidative phosphorylation; ATP synthesis
Chemical Class	Macrolide (venturicidin family)
Discovery Year	2005
Keywords	atp synthase inhibitor macrolide antibiotic polyol macrolide streptomyces metabolite antifungal compound agricultural biocontrol candidate
References	Gacem et al., Res Microbiol, 2005 DOI: 10.1016/j.resmic.2004.10.006 Gacem et al., Biotechnol J, 2008 DOI: 10.1002/biot.200700155
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

17-Hydroxyventuricidin A (CAS: 113204-43-6)