Name: Ascofuranone
Brand: Biolinks K.K.
SKU: BLK-1430

For Research Use Only. Not for human or veterinary use.

Ascofuranone (CAS: 38462-04-3) Product ID: BLK-1430 CAS 38462-04-3 Mechanism TAO inhibitor Primary Target Trypanosome alternative oxidase (TAO) Pathway Mitochondrial respiration; Parasite energy metabolism
Structure
CAS	38462-04-3
Molecular Formula	C23H29ClO5
Molecular Weight	420.94
Price	1mg: USD 520.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
Source Organism	Cosmospora sp.
Summary	Ascofuranone is a fungal isoprenoid metabolite that inhibits trypanosome alternative oxidase (TAO) in antiparasitic research.
Details	Ascofuranone is a secondary metabolite originally isolated from fungal cultures and characterized as an isoprenoid antibiotic. It strongly inhibits trypanosome alternative oxidase (TAO), a mitochondrial enzyme essential for the respiratory metabolism of Trypanosoma species. By blocking TAO, ascofuranone disrupts parasite energy production and demonstrates significant trypanocidal activity in animal models. In addition to its antiparasitic activity, ascofuranone has been reported to suppress epithelial-mesenchymal transition (EMT) and cell migration in cancer models via modulation of ERK, AKT/mTOR, and c-Myc signaling pathways. These properties position ascofuranone as a promising lead compound for antiparasitic and anticancer drug development.
Browse Related	Mechanism TAO inhibitor Open full index Primary Target Trypanosome alternative oxidase (TAO) Open full index Pathway Mitochondrial respiration; Parasite energy metabolism Open full index Chemical Class Isoprenoid meroterpenoid Open full index
Mechanism	TAO inhibitor
Primary Target	Trypanosome alternative oxidase (TAO)
Pathway	Mitochondrial respiration; Parasite energy metabolism
Chemical Class	Isoprenoid meroterpenoid
Discovery Year	1972
Keywords	trypanosome alternative oxidase inhibitor mitochondrial respiration inhibitor african trypanosomiasis research compound isoprenoid natural product fungal metabolite antiparasitic lead compound
References	Ebiloma GU et al., Onderstepoort J Vet Res, 2024, 91:e1-e7 DOI: 10.4102/ojvr.v91i1.2115 Kim YS et al., Eur J Pharmacol, 2020, 883:173199 DOI: 10.1016/j.ejphar.2020.173199 Takeuchi T et al., J Gen Appl Microbiol, 2021, 67:1-9 DOI: 10.2323/jgam.2021.08.001
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Ascofuranone (CAS: 38462-04-3)