Aspergillin PZ is an isoindole alkaloid from Aspergillus awamori featuring a distinctive oxabicyclic core.
Details
Aspergillin PZ is a fungal isoindole alkaloid isolated from Aspergillus awamori and characterized by a rare oxabicyclic ring system confirmed by X-ray crystallography. It was found to moderately induce morphological deformation of Pyricularia oryzae conidia. The structural complexity of aspergillin PZ has attracted synthetic interest, and its total synthesis was achieved via a 2-oxonia[3,3]sigmatropic rearrangement/aldol cascade mechanism. Although synthetic material showed limited cytotoxic activity, aspergillin PZ remains a notable example of a structurally remarkable fungal alkaloid.