Name: Atpenin A5
Brand: Biolinks K.K.
SKU: BLS-0330

For Research Use Only. Not for human or veterinary use.

Atpenin A5 (CAS: 119509-24-9) Product ID: BLS-0330 CAS 119509-24-9 Mechanism Complex II inhibitor Primary Target Succinate dehydrogenase (Complex II) Pathway Mitochondrial electron transport chain; TCA cycle
Structure
CAS	119509-24-9
Molecular Formula	C15H21Cl2NO5
Molecular Weight	366.24
UN (Transport)	UN2811
Price	1mg: USD 250.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
Source Organism	Synthetic
Summary	Atpenin A5 is a highly specific mitochondrial complex II inhibitor used in bioenergetics research.
Details	Atpenin A5 is a chlorinated fungal metabolite isolated from Penicillium species. It is a potent and specific inhibitor of mitochondrial complex II (succinate-ubiquinone oxidoreductase), binding to the quinone-binding pocket of succinate dehydrogenase. Atpenin A5 is widely used as a biochemical tool to investigate electron transport chain function, mitochondrial bioenergetics, reactive oxygen species production, and metabolic reprogramming in mammalian cells. It has also contributed to structural elucidation of the complex II quinone-binding site.
Browse Related	Mechanism Complex II inhibitor Open full index Primary Target Succinate dehydrogenase (Complex II) Open full index Pathway Mitochondrial electron transport chain; TCA cycle Open full index Chemical Class Chlorinated polyketide Open full index
Mechanism	Complex II inhibitor
Primary Target	Succinate dehydrogenase (Complex II)
Pathway	Mitochondrial electron transport chain; TCA cycle
Chemical Class	Chlorinated polyketide
Discovery Year	1988
Keywords	mitochondrial complex ii inhibitor succinate dehydrogenase inhibitor quinone-binding site binder mitochondrial respiration inhibitor electron transport chain inhibitor oxidative phosphorylation modulator fungal metabolite bioenergetics research tool
References	Uchida et al., J Antibiot, 1988 DOI: 10.7164/antibiotics.41.1769 Miyadera et al., PNAS, 2003 DOI: 10.1073/pnas.0237315100 Horsefield et al., J Biol Chem, 2006 DOI: 10.1074/jbc.M508173200
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Atpenin A5 (CAS: 119509-24-9)