Name: Brefeldin A
Brand: Biolinks K.K.
SKU: BLK-1680

For Research Use Only. Not for human or veterinary use.

Brefeldin A (CAS: 20350-15-6) Product ID: BLK-1680 CAS 20350-15-6 Mechanism ARF-GEF inhibitor Primary Target ADP-ribosylation factor guanine nucleotide exchange factors (ARF-GEFs; e.g., GBF1) Pathway Vesicular trafficking; ER stress response; Autophagy pathway
Structure	View full structure page Chemical structure of Brefeldin A (CAS 20350-15-6)
CAS	20350-15-6
Molecular Formula	C16H24O4
Molecular Weight	280.37
Price	1mg: - / 5mg: USD 30.00 / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Synonyms	BFA
Purity	>95%
NMR Data	1H NMR (CD3OD, 500 MHz) [View] [Full page] 13C NMR (CD3OD, 125 MHz) [View] [Full page]
NMR Spectral Data	Representative 1H NMR (CD3OD, 500 MHz) spectrum confirming the structure of Brefeldin A. Representative 13C NMR (CD3OD, 125 MHz) spectrum supporting structural assignment of Brefeldin A.
Source Organism	Lecanicillium fungicola.
Summary	Brefeldin A is a macrolide that inhibits Golgi trafficking and is widely used to induce ER stress and study autophagy.
Details	Brefeldin A is a fungal macrolide metabolite produced by several species including Fusarium and Curvularia. It inhibits ADP-ribosylation factor guanine nucleotide exchange factors (ARF-GEFs), resulting in collapse of the Golgi apparatus into the endoplasmic reticulum and disruption of vesicular trafficking. Brefeldin A is extensively used as a research tool to induce ER stress, modulate autophagy, and study membrane trafficking. It also exhibits anticancer activity through induction of apoptosis and autophagic cell death and has been investigated in colorectal cancer and chronic myeloid leukemia models.
Browse Related	Mechanism ARF-GEF inhibitor Open full index Primary Target ADP-ribosylation factor guanine nucleotide exchange factors (ARF-GEFs; e.g., GBF1) Open full index Pathway Vesicular trafficking; ER stress response; Autophagy pathway Open full index Chemical Class Macrolide lactone Open full index
Mechanism	ARF-GEF inhibitor
Primary Target	ADP-ribosylation factor guanine nucleotide exchange factors (ARF-GEFs; e.g., GBF1)
Pathway	Vesicular trafficking; ER stress response; Autophagy pathway
Chemical Class	Macrolide lactone
Discovery Year	1968
Keywords	arf-gef inhibitor golgi apparatus disruptor er stress inducer autophagy inducer apoptosis inducer macrolide antibiotic vesicular trafficking inhibitor cell biology research tool
References	Zhou et al., FASEB J, 2018 DOI: 10.1096/fj.201801983R Li et al., Toxins, 2024 DOI: 10.3390/toxins16120548 Chen et al., Curr Drug Targets, 2021 DOI: 10.2174/1871520621666210608110435
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Representative NMR Data 1H NMR (CD3OD, 500 MHz) Representative spectral data. Actual batch data may vary.
Representative NMR Data 13C NMR (CD3OD, 125 MHz) Representative spectral data. Actual batch data may vary.
Representative NMR Data 1H NMR (CD3OD, 500 MHz) 13C NMR (CD3OD, 125 MHz) Representative spectral data. Actual batch data may vary.

Brefeldin A (CAS: 20350-15-6)