Name: Chaetoglobosine A
Brand: Biolinks K.K.
SKU: BLK-1180

For Research Use Only. Not for human or veterinary use.

Chaetoglobosine A (CAS: 50335-03-0) Product ID: BLK-1180 CAS 50335-03-0 Mechanism Actin cytoskeleton inhibitor Primary Target Actin cytoskeleton (actin polymerization machinery) Pathway Actin cytoskeleton regulation
Structure
CAS	50335-03-0
Molecular Formula	C32H36N2O5
Molecular Weight	528.65
Price	1mg: USD 70.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
Source Organism	Chaetomium sp.
Summary	Chaetoglobosine A is a cytochalasan that disrupts actin dynamics and exhibits antifungal and cytotoxic activity.
Details	Chaetoglobosin A is a cytochalasan-type secondary metabolite produced by Chaetomium globosum via a PKS-NRPS hybrid biosynthetic pathway. Structurally related to cytochalasins, it disrupts actin polymerization and exhibits potent antifungal, antiparasitic, and antitumor activities. Genetic studies have shown that pathway-specific regulators and transporters strongly influence chaetoglobosin A biosynthesis and secretion. It contributes significantly to the biocontrol activity of Chaetomium strains against plant pathogens and has been investigated for agricultural and biomedical applications. Toxicological studies demonstrate cytotoxic effects consistent with actin-disrupting compounds.
Browse Related	Mechanism Actin cytoskeleton inhibitor Open full index Primary Target Actin cytoskeleton (actin polymerization machinery) Open full index Pathway Actin cytoskeleton regulation Open full index Chemical Class Cytochalasan (PKS–NRPS hybrid) Open full index
Mechanism	Actin cytoskeleton inhibitor
Primary Target	Actin cytoskeleton (actin polymerization machinery)
Pathway	Actin cytoskeleton regulation
Chemical Class	Cytochalasan (PKS–NRPS hybrid)
Discovery Year	1973
Keywords	actin polymerization inhibitor cytochalasan pks-nrps hybrid metabolite antifungal compound antitumor agent chaetomium metabolite fungal mycotoxin cytoskeleton research tool
References	Yang et al., Fungal Biol, 2021 DOI: 10.1016/j.funbio.2020.10.010 Wang et al., Phytopathology, 2023 DOI: 10.1094/PHYTO-01-23-0036-R Zhang et al., Microb Biotechnol, 2023 DOI: 10.1111/1751-7915.14111
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Chaetoglobosine A (CAS: 50335-03-0)