Name: Dimerumic acid
Brand: Biolinks K.K.
SKU: BLK-1630

For Research Use Only. Not for human or veterinary use.

Dimerumic acid (CAS: 26912-16-3) Product ID: BLK-1630 CAS 26912-16-3 Mechanism Iron chelator Primary Target Ferric iron (Fe3+) Pathway Iron acquisition pathway; Oxidative stress response
Structure
CAS	26912-16-3
Molecular Formula	C22H36N4O8
Molecular Weight	484.55
Price	1mg: USD 360.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
NMR Data	1H NMR (DMSO-d6, 500 MHz) [View]
Source Organism	Pochonia sp.
Summary	Dimerumic acid is a hydroxamate siderophore that chelates iron and is used in oxidative stress research.
Details	Dimerumic acid is a fungal hydroxamic acid-containing siderophore identified as a cleavage product of coprogen-type iron chelators and independently produced by several fungi. It functions as an iron-chelating metabolite under iron-deficient conditions and is biosynthesized via NRPS-dependent pathways. Mechanistically, dimerumic acid donates an electron through its hydroxamic acid group to neutralize reactive oxygen species, forming a nitroxide radical and inhibiting lipid peroxidation. It protects hepatocytes from oxidative stress-induced cytotoxicity and serves as a chemical probe for studying iron homeostasis and antioxidant defense.
Browse Related	Mechanism Iron chelator Open full index Primary Target Ferric iron (Fe3+) Open full index Pathway Iron acquisition pathway; Oxidative stress response Open full index Chemical Class Cyclic trihydroxamate siderophore Open full index
Mechanism	Iron chelator
Primary Target	Ferric iron (Fe3+)
Pathway	Iron acquisition pathway; Oxidative stress response
Chemical Class	Cyclic trihydroxamate siderophore
Discovery Year	1985
Keywords	iron chelator hydroxamate siderophore lipid peroxidation inhibitor antioxidant compound nrps-derived metabolite fungal metabolite oxidative stress research tool
References	Llinas et al., Biochemistry, 1985 DOI: 10.1021/bi00512a011 Akihisa et al., Biochem Pharmacol, 2001 DOI: 10.1016/S0006-2952(01)00923-6 Zhang et al., Front Microbiol, 2021 DOI: 10.3389/fmicb.2021.783609 Honda et al., Cell Biol Toxicol, 2008 DOI: 10.1007/s10565-007-9037-7
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Representative NMR Data 1H NMR (DMSO-d6, 500 MHz) Representative spectral data. Actual batch data may vary.

Dimerumic acid (CAS: 26912-16-3)