Name: (-)-Flavomannin A
Brand: Biolinks K.K.
SKU: BLK-1500

For Research Use Only. Not for human or veterinary use.

(-)-Flavomannin A (CAS: 19953-89-0) Product ID: BLK-1500 CAS 19953-89-0 Mechanism Cell-cycle arrest inducer Primary Target Cell-cycle regulatory proteins Pathway Cell cycle regulation; Antiplasmodial pathway
Structure
CAS	19953-89-0
Molecular Formula	C30H26O10
Molecular Weight	546.54
Price	1mg: USD 360.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
NMR Data	1H NMR (CD3OD, 500 MHz) [View] 13C NMR (CD3OD, 125 MHz) [View]
Source Organism	Talaromyces sp.
Summary	(-)-Flavomannin A is a fungal anthranoid pigment with antiproliferative activity and relevance as an antiplasmodial-related scaffold.
Details	Flavomannin A is a preanthraquinone anthranoid pigment isolated from Cortinarius and related fungal species. Structurally related flavomannins have demonstrated moderate antiplasmodial activity against Plasmodium falciparum and antiproliferative effects in human cancer cell lines. In colorectal Caco-2 cells, flavomannin derivatives induce G0/G1 cell-cycle arrest accompanied by upregulation of p27 without triggering apoptosis. As an anthranoid scaffold linked to both cytostatic and antimalarial activities, flavomannin A serves as a valuable natural product framework for structure-activity relationship studies.
Browse Related	Mechanism Cell-cycle arrest inducer Open full index Primary Target Cell-cycle regulatory proteins Open full index Pathway Cell cycle regulation; Antiplasmodial pathway Open full index Chemical Class Anthranoid Open full index
Mechanism	Cell-cycle arrest inducer
Primary Target	Cell-cycle regulatory proteins
Pathway	Cell cycle regulation; Antiplasmodial pathway
Chemical Class	Anthranoid
Discovery Year	1999
Keywords	anthranoid pigment antiproliferative compound g0 g1 cell cycle arrest inducer antiplasmodial scaffold fungal secondary metabolite natural product research tool
References	Bringmann et al., Parasitol Res, 1999 DOI: 10.1007/s004360050598 Sousa et al., Toxicology, 2009 DOI: 10.1016/j.tox.2009.08.009 Geroldinger et al., Mycol Prog, 2021 DOI: 10.1007/s43630-021-00159-y
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Representative NMR Data 1H NMR (CD3OD, 500 MHz) Representative spectral data. Actual batch data may vary.
Representative NMR Data 13C NMR (CD3OD, 125 MHz) Representative spectral data. Actual batch data may vary.
Representative NMR Data 1H NMR (CD3OD, 500 MHz) 13C NMR (CD3OD, 125 MHz) Representative spectral data. Actual batch data may vary.

(-)-Flavomannin A (CAS: 19953-89-0)