Name: Neoxaline
Brand: Biolinks K.K.
SKU: BLK-0530

For Research Use Only. Not for human or veterinary use.

Neoxaline (CAS: 71812-10-7) Product ID: BLK-0530 CAS 71812-10-7 Mechanism CNS stimulant alkaloid Primary Target Not identified Pathway Neuroactive signaling pathways
Structure
CAS	71812-10-7
Molecular Formula	C23H25N5O4
Molecular Weight	435.48
Price	1mg: USD 90.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
Source Organism	Aspergillus japonicus.
Summary	Neoxaline is a fungal indoline spiroaminal alkaloid with weak central nervous system activity.
Details	Neoxaline is a prenylated indoline spiroaminal alkaloid isolated from Aspergillus japonicus. Structurally characterized by a tetracyclic indoline spiroaminal framework containing a reverse-prenyl group and a dehydrohistidine-derived unit, it represents a unique fungal alkaloid scaffold. Although it lacks antimicrobial activity, neoxaline exhibits weak central nervous system stimulant effects, indicating interaction with neuroactive pathways. It has primarily served as a structural and synthetic target, with multiple stereoselective total syntheses establishing its absolute configuration and highlighting its complex spirocyclic architecture.
Browse Related	Mechanism CNS stimulant alkaloid Open full index Primary Target Not identified Open full index Pathway Neuroactive signaling pathways Open full index Chemical Class Prenylated indoline spiroaminal alkaloid Open full index
Mechanism	CNS stimulant alkaloid
Primary Target	Not identified
Pathway	Neuroactive signaling pathways
Chemical Class	Prenylated indoline spiroaminal alkaloid
Discovery Year	1979
Keywords	indoline spiroaminal alkaloid prenylated fungal alkaloid cns stimulant natural product aspergillus japonicus metabolite heterocyclic alkaloid scaffold
References	Uchida et al., J Antibiot, 1979 DOI: 10.7164/antibiotics.32.781 Lanman et al., Org Lett, 2005 DOI: 10.1021/ol050077y Kim et al., J Am Chem Soc, 2013 DOI: 10.1021/ja406657v
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Neoxaline (CAS: 71812-10-7)