Name: Penicillide
Brand: Biolinks K.K.
SKU: BLK-1060

For Research Use Only. Not for human or veterinary use.

Penicillide (CAS: 55303-92-9) Product ID: BLK-1060 CAS 55303-92-9 Mechanism ACAT inhibitor Primary Target Acyl-CoA:cholesterol acyltransferase (ACAT) Pathway Cholesterol esterification pathway
Structure
CAS	55303-92-9
Molecular Formula	C21H24O6
Molecular Weight	372.42
Price	1mg: USD 140.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
Source Organism	Penicillium sp.
Summary	Penicillide is a fungal depsidone metabolite that inhibits ACAT and affects cholesterol esterification.
Details	Penicillide is a depsidone-type secondary metabolite frequently isolated from Penicillium and Talaromyces species and recognized as the founder compound of the penicillide family. It has been studied for its inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT), a key enzyme in cholesterol esterification and foam-cell formation. Structure-activity studies of acylated derivatives revealed that small acyl substitutions enhance ACAT inhibitory potency and selectivity in macrophage models. Beyond lipid-metabolism research, penicillide derivatives exhibit antifungal and ecological bioactivities, supporting a potential role in fungal defense. Penicillide therefore represents a useful scaffold for studying cholesterol metabolism and fungal secondary metabolite diversification.
Browse Related	Mechanism ACAT inhibitor Open full index Primary Target Acyl-CoA:cholesterol acyltransferase (ACAT) Open full index Pathway Cholesterol esterification pathway Open full index Chemical Class Depsidone Open full index
Mechanism	ACAT inhibitor
Primary Target	Acyl-CoA:cholesterol acyltransferase (ACAT)
Pathway	Cholesterol esterification pathway
Chemical Class	Depsidone
Discovery Year	1991
Keywords	sterol o-acyltransferase (acat) inhibitor cholesterol esterification inhibitor lipid metabolism modulator depsidone natural product fungal metabolite metabolic research tool
References	Tomoda et al., J Antibiot, 1991 DOI: 10.7164/antibiotics.44.152 Takahashi et al., J Antibiot, 2005 DOI: 10.1007/s11418-005-0028-9 Kurobane et al., Molecules, 2024 DOI: 10.3390/molecules29163888
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Penicillide (CAS: 55303-92-9)