Name: Citrinin
Brand: Biolinks K.K.
SKU: BLK-0390

For Research Use Only. Not for human or veterinary use.

Citrinin (CAS: 518-75-2) Product ID: BLK-0390 CAS 518-75-2 Mechanism ROS inducer Primary Target Cellular antioxidant response regulators Pathway Oxidative stress response; Cellular detoxification signaling
Structure
CAS	518-75-2
Molecular Formula	C13H14O5
Molecular Weight	250.25
UN (Transport)	UN2811
Price	1mg: USD 27.00 / 5mg: USD 98.00 / 25mg: USD 350.00
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
Source Organism	Penicillium citrinum.
Summary	Citrinin is a nephrotoxic fungal polyketide mycotoxin widely used to model oxidative stress.
Details	Citrinin is a polyketide mycotoxin produced by several Penicillium and Aspergillus species and is frequently detected as a food contaminant. It is associated with nephrotoxicity and has been implicated in Balkan endemic nephropathy. Mechanistic studies in yeast demonstrate that citrinin induces strong oxidative stress, activates Yap1/Skn7-dependent antioxidant pathways, and stimulates multidrug resistance transport systems. Citrinin is widely used as a research tool to study oxidative stress responses, mycotoxin toxicity, and cellular detoxification mechanisms.
Browse Related	Mechanism ROS inducer Open full index Primary Target Cellular antioxidant response regulators Open full index Pathway Oxidative stress response; Cellular detoxification signaling Open full index Chemical Class Polyketide mycotoxin Open full index
Mechanism	ROS inducer
Primary Target	Cellular antioxidant response regulators
Pathway	Oxidative stress response; Cellular detoxification signaling
Chemical Class	Polyketide mycotoxin
Discovery Year	1931
Keywords	nephrotoxic mycotoxin oxidative stress inducer reactive oxygen species generator food contaminant toxin fungal polyketide penicillium metabolite aspergillus metabolite toxicology research tool
References	Hetherington & Raistrick, Biochem J, 1931 DOI: 10.1042/bj0250470 Oxford & Raistrick, Nature, 1947 DOI: 10.1038/160331b0 Iwahashi et al., Nutrients, 2014 DOI: 10.3390/nu6052077 Iwahashi et al., Toxins, 2016 DOI: 10.3390/toxins8100273
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Citrinin (CAS: 518-75-2)