Name: Radicicol
Brand: Biolinks K.K.
SKU: BLK-0500

For Research Use Only. Not for human or veterinary use.

Radicicol (CAS: 12772-57-5) Product ID: BLK-0500 CAS 12772-57-5 Mechanism Hsp90 inhibitor Primary Target Hsp90 Pathway Protein folding pathway; Oncogenic signaling
Structure
CAS	12772-57-5
Molecular Formula	C18H17ClO6
Molecular Weight	364.78
UN (Transport)	UN2811
Price	1mg: USD 36.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Synonyms	Monorden
Purity	>95% [View LC/UV Data]
Source Organism	Pochonia sp.
Summary	Radicicol is a resorcylic acid lactone that inhibits Hsp90.
Details	Radicicol is a fungal secondary metabolite originally identified as an antibiotic and later established as a potent ATP-competitive inhibitor of heat shock protein 90 (Hsp90). It binds to the N-terminal ATP-binding pocket of Hsp90 and blocks its chaperone cycle, leading to destabilization and degradation of oncogenic client proteins including Raf-1, HER2, and mutant p53. Structural and biochemical studies confirmed its occupation of the nucleotide-binding site and its role in suppressing oncogenic signaling.
Browse Related	Mechanism Hsp90 inhibitor Open full index Primary Target Hsp90 Open full index Pathway Protein folding pathway; Oncogenic signaling Open full index Chemical Class Resorcylic acid lactone (RAL) Open full index
Mechanism	Hsp90 inhibitor
Primary Target	Hsp90
Pathway	Protein folding pathway; Oncogenic signaling
Chemical Class	Resorcylic acid lactone (RAL)
Discovery Year	1953
Keywords	hsp90 inhibitor resorcylic acid lactone atp-competitive inhibitor oncogenic client protein degradation inducer fungal macrolide chemical biology probe
References	Delmotte et al., Nature, 1953 DOI: 10.1038/171344a0 Schulte et al., J Biol Chem, 1998 DOI: 10.1074/jbc.273.25.15564 Soga et al., Cancer Res, 1998 DOI: 10.1158/0008-5472.CAN-98-0588 Roe et al., J Med Chem, 1999 DOI: 10.1021/jm990095i Chiosis et al., Mol Cancer Ther, 2001 DOI: 10.1158/1535-7163.MCT-01-0004
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Radicicol (CAS: 12772-57-5)