Name: Pyripyropene A
Brand: Biolinks K.K.
SKU: BLK-0570

For Research Use Only. Not for human or veterinary use.

Pyripyropene A (CAS: 147444-03-9) Product ID: BLK-0570 CAS 147444-03-9 Mechanism SOAT2 inhibitor Primary Target Sterol O-acyltransferase 2 (SOAT2; ACAT2) Pathway Cholesterol esterification
Structure
CAS	147444-03-9
Molecular Formula	C31H37NO10
Molecular Weight	583.64
Price	1mg: USD 360.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
Source Organism	Aspergillus fumigatus.
Summary	Pyripyropene A is a fungal meroterpenoid that selectively inhibits sterol O-acyltransferase 2 (SOAT2/ACAT2).
Details	Pyripyropene A is a secondary metabolite produced by Aspergillus fumigatus and represents one of the most potent and selective inhibitors of sterol O-acyltransferase 2 (SOAT2), also known as ACAT2. It inhibits cholesterol esterification in microsomal assays with nanomolar potency and shows strong isozyme selectivity over SOAT1. Structure-activity relationship studies and synthetic analogue development confirmed its role as a lead compound for dyslipidemia and anti-atherosclerotic drug discovery. In addition to its lipid-metabolism activity, pyripyropene A exhibits strong insecticidal activity against aphids and other sap-sucking agricultural pests.
Browse Related	Mechanism SOAT2 inhibitor Open full index Primary Target Sterol O-acyltransferase 2 (SOAT2; ACAT2) Open full index Pathway Cholesterol esterification Open full index Chemical Class Meroterpenoid Open full index
Mechanism	SOAT2 inhibitor
Primary Target	Sterol O-acyltransferase 2 (SOAT2; ACAT2)
Pathway	Cholesterol esterification
Chemical Class	Meroterpenoid
Discovery Year	1994
Keywords	sterol o-acyltransferase 2 (soat2) inhibitor acat2 selective inhibitor cholesterol esterification inhibitor aspergillus fumigatus metabolite anti-atherosclerotic lead compound
References	Omura et al., J Antibiot, 1994 DOI: 10.7164/antibiotics.47.148 Yoshida et al., ChemMedChem, 2017 DOI: 10.1002/cmdc.201700645 Kakeya et al., J Antibiot, 2016 DOI: 10.1038/ja.2016.155 Matsuo et al., J Pestic Sci, 2019 DOI: 10.1584/jpestics.D18-030
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Pyripyropene A (CAS: 147444-03-9)