Name: Territrem B
Brand: Biolinks K.K.
SKU: BLK-0600

For Research Use Only. Not for human or veterinary use.

Territrem B (CAS: 70407-20-4) Product ID: BLK-0600 CAS 70407-20-4 Mechanism Acetylcholinesterase inhibitor Primary Target Acetylcholinesterase (AChE) Pathway Cholinergic neurotransmission pathway
Structure
CAS	70407-20-4
Molecular Formula	C29H34O9
Molecular Weight	526.58
Price	1mg: USD 200.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
NMR Data	1H NMR (CDCl3, 500 MHz) [View]
Source Organism	Penicillium sp.
Summary	Territrem B is a tremorgenic mycotoxin that potently inhibits acetylcholinesterase.
Details	Territrem B is a tremorgenic fungal mycotoxin isolated from Aspergillus terreus and originally characterized together with territrem A. Biochemical studies demonstrated that territrem B is a potent inhibitor of acetylcholinesterase (AChE), exhibiting noncovalent yet functionally irreversible inhibition with quasi-first-order kinetics and one-to-one stoichiometry. Binding studies and X-ray crystallography revealed that territrem B spans the peripheral (P) site and extends into the acylation (A) site at the base of the active-site gorge, where it becomes tightly trapped within the gorge structure. This unique binding mode explains its high affinity and persistent inhibition, distinct from that of classical covalent organophosphate inhibitors. Immunoelectron microscopy further localized territrem B production to conidia of A. terreus, consistent with its classification as a tremorgenic neurotoxic mycotoxin.
Browse Related	Mechanism Acetylcholinesterase inhibitor Open full index Primary Target Acetylcholinesterase (AChE) Open full index Pathway Cholinergic neurotransmission pathway Open full index Chemical Class Tremorgenic polyketide Open full index
Mechanism	Acetylcholinesterase inhibitor
Primary Target	Acetylcholinesterase (AChE)
Pathway	Cholinergic neurotransmission pathway
Chemical Class	Tremorgenic polyketide
Discovery Year	1979
Keywords	acetylcholinesterase (ache) inhibitor tremorgenic mycotoxin noncovalent active-site binder aspergillus terreus metabolite neurotoxin natural product research tool
References	Springer et al., Appl Environ Microbiol, 1979 (isolation and characterization of territrems A and B) DOI: 10.1128/aem.37.3.355-357.1979 Harel et al., J Mol Neurosci, 2014 (AChE crystal structure; P-site and A-site binding) DOI: 10.1007/s12031-014-0261-3 Huang et al., J Biol Chem, 1999 (noncovalent irreversible AChE inhibition kinetics and mechanism) DOI: 10.1074/jbc.274.49.34916 Wu et al., J Agric Food Chem, 2004 (immunoelectron microscopy; localization in conidia) DOI: 10.1021/jf030787n
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.
Representative NMR Data 1H NMR (CDCl3, 500 MHz) Representative spectral data. Actual batch data may vary.

Territrem B (CAS: 70407-20-4)