Name: Cyclopenin
Brand: Biolinks K.K.
SKU: BLK-0770

For Research Use Only. Not for human or veterinary use.

Cyclopenin (CAS: 19553-26-5) Product ID: BLK-0770 CAS 19553-26-5 Mechanism NF-κB inhibitor Primary Target SARS-CoV-2 main protease (Mpro); NF-κB signaling components Pathway Viral polyprotein processing; NF-κB signaling pathway
Structure
CAS	19553-26-5
Molecular Formula	C17H14N2O3
Molecular Weight	294.31
Price	1mg: USD 170.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
Source Organism	Penicillium sp.
Summary	Cyclopenin is a benzodiazepine alkaloid that inhibits NF-κB signaling and SARS-CoV-2 Mpro.
Details	Cyclopenin is a benzodiazepine alkaloid produced by Penicillium and Aspergillus species and belongs to the cyclopenin-cyclopenol metabolite family. Recent studies demonstrate that cyclopenin inhibits SARS-CoV-2 main protease (Mpro) in vitro at submicromolar concentrations and suppresses LPS-induced NF-κB activation, reducing nitric oxide and pro-inflammatory cytokine production. In cellular models, it downregulates iNOS, IL-1β, and IL-6 expression and ameliorates inflammation-associated phenotypes. Cyclopenin thus functions as a dual anti-inflammatory and antiviral scaffold with value in chemical biology and drug discovery research.
Browse Related	Mechanism NF-κB inhibitor Open full index Primary Target SARS-CoV-2 main protease (Mpro); NF-κB signaling components Open full index Pathway Viral polyprotein processing; NF-κB signaling pathway Open full index Chemical Class Benzodiazepine alkaloid Open full index
Mechanism	NF-κB inhibitor
Primary Target	SARS-CoV-2 main protease (Mpro); NF-κB signaling components
Pathway	Viral polyprotein processing; NF-κB signaling pathway
Chemical Class	Benzodiazepine alkaloid
Discovery Year	1976
Keywords	sars-cov-2 mpro inhibitor nf-κb pathway inhibitor anti-inflammatory compound nitric oxide production suppressor benzodiazepine alkaloid penicillium metabolite antiviral research scaffold
References	Anke et al., J Basic Microbiol, 1984 DOI: 10.1002/jobm.3630240908 Elissawy et al., Biomolecules, 2021 DOI: 10.3390/biom11091366 Chen et al., Pharmacol Res, 2020 DOI: 10.1038/s41429-020-0302-9
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Cyclopenin (CAS: 19553-26-5)