Name: 11-O-Methylpseurotin A
Brand: Biolinks K.K.
SKU: BLK-0930

For Research Use Only. Not for human or veterinary use.

11-O-Methylpseurotin A (CAS: 956904-34-0) Product ID: BLK-0930 CAS 956904-34-0 Mechanism Synthetic lethality probe Primary Target Not identified Pathway Cytokinesis pathway
Structure
CAS	956904-34-0
Molecular Formula	C23H27NO8
Molecular Weight	445.47
Price	1mg: USD 140.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
Source Organism	Sporothrix sp.
Summary	11-O-Methylpseurotin A is a PKS-NRPS–derived pseurotin analogue used as a chemical genetics probe.
Details	11-O-Methylpseurotin A is a PKS-NRPS hybrid secondary metabolite isolated from marine-derived Aspergillus fumigatus. Identified through a synthetic-lethality yeast screen, it selectively inhibits a Hof1 deletion strain of Saccharomyces cerevisiae, suggesting interference with cytokinesis or cell-cycle regulation. Structurally related to pseurotin A, it belongs to the heterospirocyclic γ-lactam family of pseurotins. Although its direct molecular target remains undefined, its selective activity makes it a valuable chemical-genetics tool for probing cell-division pathways.
Browse Related	Mechanism Synthetic lethality probe Open full index Primary Target Not identified Open full index Pathway Cytokinesis pathway Open full index Chemical Class PKS–NRPS hybrid spiro-γ-lactam Open full index
Mechanism	Synthetic lethality probe
Primary Target	Not identified
Pathway	Cytokinesis pathway
Chemical Class	PKS–NRPS hybrid spiro-γ-lactam
Discovery Year	2007
Keywords	pks-nrps hybrid metabolite synthetic lethality probe cell cycle inhibitor aspergillus fumigatus metabolite chemical genetics research tool
References	Belofsky et al., J Nat Prod, 2007 DOI: 10.1021/np070307c Brunhofer et al., ACS Chem Neurosci, 2018 DOI: 10.1021/acschemneuro.8b00060 Rateb et al., Front Microbiol, 2017 DOI: 10.3389/fmicb.2017.01284
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

11-O-Methylpseurotin A (CAS: 956904-34-0)