Name: Amauromine
Brand: Biolinks K.K.
SKU: BLK-1040

For Research Use Only. Not for human or veterinary use.

Amauromine (CAS: 88360-87-6) Product ID: BLK-1040 CAS 88360-87-6 Mechanism GPCR antagonist Primary Target Cannabinoid CB1 receptor; GPR18 Pathway GPCR signaling pathway; Vascular tone regulation; Cannabinoid receptor signaling
Structure
CAS	88360-87-6
Molecular Formula	C32H36N4O2
Molecular Weight	508.66
Price	1mg: USD 140.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
Source Organism	Gymnascella sp.
Summary	Amauromine is a fungal diketopiperazine alkaloid that modulates GPCR signaling by inhibiting CB1 and GPR18 receptors.
Details	Amauromine is a fungal-derived diketopiperazine alkaloid originally isolated from Amauroascus sp. as a vasodilatory compound with low acute toxicity in mice. Structural characterization established the molecular formula C32H36N4O2. Subsequent studies revealed that amauromine acts as a cannabinoid receptor antagonist, inhibiting CB1 receptors (Ki = 0.178 µM) and exhibiting antagonistic activity at the orphan receptor GPR18 (IC50 = 3.74 µM), thereby identifying it as a bioactive GPCR modulator. Related diketopiperazine analogues isolated from Aspergillus terreus showed α-glucosidase inhibitory activity, further supporting the pharmacological relevance of this structural class. These data establish amauromine as a multifunctional fungal alkaloid with vasodilatory and receptor-modulating properties and potential utility as a lead structure for GPCR-targeted research.
Browse Related	Mechanism GPCR antagonist Open full index Primary Target Cannabinoid CB1 receptor; GPR18 Open full index Pathway GPCR signaling pathway; Vascular tone regulation; Cannabinoid receptor signaling Open full index Chemical Class Diketopiperazine alkaloid Open full index
Mechanism	GPCR antagonist
Primary Target	Cannabinoid CB1 receptor; GPR18
Pathway	GPCR signaling pathway; Vascular tone regulation; Cannabinoid receptor signaling
Chemical Class	Diketopiperazine alkaloid
Discovery Year	1984
Keywords	cannabinoid cb1 receptor antagonist gpr18 antagonist gpcr modulator vasodilatory activity α-glucosidase inhibitor diketopiperazine alkaloid fungal metabolite gpcr signaling research tool
References	Kobayashi H et al., J Antibiot (Tokyo), 1984, 37:1320-1327 DOI: 10.7164/antibiotics.37.1320 Pacher T et al., Chem Biodivers, 2015, 12(7):1049-1056 DOI: 10.1002/cbdv.201500027
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Amauromine (CAS: 88360-87-6)