Name: Concanamycin B
Brand: Biolinks K.K.
SKU: BLK-1160

For Research Use Only. Not for human or veterinary use.

Concanamycin B (CAS: 81552-33-2) Product ID: BLK-1160 CAS 81552-33-2 Mechanism V-ATPase inhibitor Primary Target Vacuolar-type H+-ATPase (V-ATPase) Pathway Endosomal–lysosomal acidification pathway
Structure
CAS	81552-33-2
Molecular Formula	C45H73NO14
Molecular Weight	852.08
Price	1mg: USD 360.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
Source Organism	Streptomyces sp.
Summary	Concanamycin B is a V-ATPase–specific macrolide inhibitor that blocks lysosomal acidification.
Details	Concanamycin B is an 18-membered macrolide antibiotic isolated from Streptomyces diastatochromogenes and belongs to the concanamycin/folimycin family. It specifically inhibits vacuolar-type H+-ATPase (V-ATPase), thereby preventing ATP-dependent acidification of endosomes, lysosomes, and osteoclastic resorption lacunae. Through inhibition of organelle acidification, concanamycin B suppresses antigen presentation via MHC class II and blocks osteoclast-mediated bone resorption. It is widely used as a mechanistic probe to study vesicular trafficking, receptor recycling, lysosomal function, and pH-dependent cellular processes.
Browse Related	Mechanism V-ATPase inhibitor Open full index Primary Target Vacuolar-type H+-ATPase (V-ATPase) Open full index Pathway Endosomal–lysosomal acidification pathway Open full index Chemical Class 18-membered macrolide Open full index
Mechanism	V-ATPase inhibitor
Primary Target	Vacuolar-type H+-ATPase (V-ATPase)
Pathway	Endosomal–lysosomal acidification pathway
Chemical Class	18-membered macrolide
Discovery Year	1984
Keywords	v-atpase inhibitor macrolide antibiotic proton pump inhibitor endosomal acidification blocker lysosomal ph modulator osteoclast activity inhibitor fungal-active antibiotic cell biology mechanistic probe
References	Kinashi et al., J Antibiot, 1984 DOI: 10.7164/antibiotics.37.1333 Nishimura et al., Biol Pharm Bull, 1996 DOI: 10.1248/bpb.19.297 Kuwana et al., J Antibiot, 1995 DOI: 10.7164/antibiotics.48.488 Uchida et al., Eur J Biochem, 1992 DOI: 10.1111/j.1432-1033.1992.tb17061.x
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Concanamycin B (CAS: 81552-33-2)