OM173-alphaA is a nanaomycin-type polyketide antibiotic active against mycoplasmas and fungi.
Details
OM173-alphaA is one of several nanaomycin-type antibiotics produced by Streptomyces sp. OM-173. Structurally belonging to the benzoisochromanequinone family of polyketide-derived antibiotics, it shares biosynthetic homology with actinorhodin- and kalafungin-type compounds. OM173-alphaA exhibits activity against mycoplasmas and moderate antifungal effects, consistent with quinone-containing redox-active antibiotics. Biosynthetic gene cluster analysis indicates PKS-derived assembly closely related to nanaomycin and kalafungin pathways. The compound represents a useful scaffold for studying polyketide quinone antibiotic biosynthesis and redox-mediated antimicrobial mechanisms.