Talarolutin D is a meroterpenoid isolated from Talaromyces minioluteus.
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Talarolutin D is one of four meroterpenoids (talarolutins A-D) isolated from an endophytic fungal strain of Talaromyces minioluteus obtained from the leaves of Silybum marianum. Its structure was elucidated using NMR and MS analyses, with stereochemical assignments supported by NOESY and ECD comparisons within the talarolutin series. In biological evaluation, talarolutins B-D were tested for cytotoxicity against human prostate carcinoma (PC-3) cells, antimicrobial activity, and induction of quinone reductase, but no notable activity was observed in these assays. Thus, talarolutin D is currently characterized primarily as a structurally defined fungal meroterpenoid without confirmed bioactivity.