Name: PF1140
Brand: Biolinks K.K.
SKU: BLK-1610

For Research Use Only. Not for human or veterinary use.

PF1140 (CAS: 173560-58-2) Product ID: BLK-1610 CAS 173560-58-2 Mechanism Iron chelator Primary Target Ferric iron (Fe3+) Pathway Iron homeostasis; Oxidative stress response
Structure
CAS	173560-58-2
Molecular Formula	C16H23NO3
Molecular Weight	277.37
Price	1mg: USD 360.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
NMR Data	1H NMR (CD3OD, 500 MHz) [View] 13C NMR (CD3OD, 125 MHz) [View]
Source Organism	Penicillium raphiae.
Summary	PF1140 is a fungal N-hydroxypyridone natural product that chelates iron and exhibits antifungal activity.
Details	PF1140 is an N-hydroxypyridone secondary metabolite isolated from various Penicillium species and structurally characterized by X-ray crystallography. Its N-hydroxypyridone moiety enables strong Fe3+ chelation, conferring siderophore-like properties under physiological conditions. PF1140 exhibits antifungal activity, notably against Hymenoscyphus fraxineus, and has demonstrated antibacterial effects against Mycoplasma genitalium, potentially via iron-mediated oxidative stress. These properties highlight its role in fungal chemical ecology and iron-dependent cytotoxicity mechanisms. PF1140 represents a valuable scaffold for studying iron-binding natural products and redox-driven antimicrobial activity.
Browse Related	Mechanism Iron chelator Open full index Primary Target Ferric iron (Fe3+) Open full index Pathway Iron homeostasis; Oxidative stress response Open full index Chemical Class N-Hydroxypyridone alkaloid Open full index
Mechanism	Iron chelator
Primary Target	Ferric iron (Fe3+)
Pathway	Iron homeostasis; Oxidative stress response
Chemical Class	N-Hydroxypyridone alkaloid
Discovery Year	2005
Keywords	iron chelator n-hydroxypyridone metabolite antifungal compound penicillium metabolite siderophore-like natural product iron biology research tool
References	Harrison et al., J Antibiot, 2005 DOI: 10.1038/ja.2005.56 Bremner et al., J Nat Prod, 2008 DOI: 10.1021/np800627f Müller et al., Appl Environ Microbiol, 2024 DOI: 10.1128/aem.00665-24 Smith et al., J Nat Prod, 2024 DOI: 10.1021/acs.jnatprod.4c00209
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Representative NMR Data 1H NMR (CD3OD, 500 MHz) Representative spectral data. Actual batch data may vary.
Representative NMR Data 13C NMR (CD3OD, 125 MHz) Representative spectral data. Actual batch data may vary.
Representative NMR Data 1H NMR (CD3OD, 500 MHz) 13C NMR (CD3OD, 125 MHz) Representative spectral data. Actual batch data may vary.

PF1140 (CAS: 173560-58-2)