Name: Pycnidione
Brand: Biolinks K.K.
SKU: BLK-1660
Price: 360.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Pycnidione (CAS: 149064-34-6) Product ID: BLK-1660 CAS 149064-34-6 Mechanism Checkpoint kinase inhibitor Primary Target Checkpoint kinase 1 (Chk1); Checkpoint kinase 2 (Chk2) Pathway DNA damage response; G2 checkpoint pathway
Structure	View full structure page Chemical structure of Pycnidione (CAS 149064-34-6)
CAS	149064-34-6
Molecular Formula	C33H40O7
Molecular Weight	548.68
Price	1mg: USD 360.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
NMR Data	1H NMR (CDCl3, 500 MHz) [View] [Full page]
NMR Spectral Data	Representative 1H NMR (CDCl3, 500 MHz) spectrum confirming the structure of Pycnidione. Representative 13C NMR (CDCl3, 125 MHz) spectrum supporting structural assignment of Pycnidione.
Source Organism	Coniochaeta sp.
Summary	Pycnidione is a fungal tropolone meroterpenoid that disrupts the G2 checkpoint and induces apoptosis.
Details	Pycnidione is a tropolone-containing meroterpenoid natural product originally isolated from fungal sources and biosynthetically formed via an intermolecular hetero Diels-Alder reaction between a tropolone polyketide and humulene. It exhibits potent antiproliferative activity in cancer cells, inducing G1 arrest and apoptosis through ROS generation, mitochondrial membrane depolarization, and caspase activation. Importantly, pycnidione abrogates DNA damage-induced G2 arrest by downregulating Chk1 and Chk2, thereby sensitizing cells to chemotherapeutic agents such as bleomycin. Recent synthetic and synthetic biology studies have clarified its stereochemistry and expanded the accessible tropolone sesquiterpenoid scaffold. Pycnidione therefore represents a valuable chemical probe for studying DNA damage checkpoints and redox-driven apoptosis.
Browse Related	Mechanism Checkpoint kinase inhibitor Open full index Primary Target Checkpoint kinase 1 (Chk1); Checkpoint kinase 2 (Chk2) Open full index Pathway DNA damage response; G2 checkpoint pathway Open full index Chemical Class Tropolone meroterpenoid Open full index
Mechanism	Checkpoint kinase inhibitor
Primary Target	Checkpoint kinase 1 (Chk1); Checkpoint kinase 2 (Chk2)
Pathway	DNA damage response; G2 checkpoint pathway
Chemical Class	Tropolone meroterpenoid
Discovery Year	1999
Keywords	g2 checkpoint inhibitor chk1 pathway modulator ros inducer apoptosis inducer tropolone meroterpenoid fungal natural product cell cycle research tool
References	Porco et al., Org Lett, 1999 DOI: 10.1021/ol991067y Kim et al., Chem Biol Interact, 2012 DOI: 10.1016/j.cbi.2012.03.004 Ito et al., Biol Pharm Bull, 2012 DOI: 10.1248/bpb.35.18 Sun et al., Angew Chem Int Ed, 2020 DOI: 10.1002/anie.202009914 Smith et al., J Am Chem Soc, 2021 DOI: 10.1021/jacs.1c02150
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Representative NMR Data 1H NMR (CDCl3, 500 MHz) Representative spectral data. Actual batch data may vary.

Pycnidione (CAS: 149064-34-6)