Name: Pyridoxatin
Brand: Biolinks K.K.
SKU: BLK-1080

For Research Use Only. Not for human or veterinary use.

Pyridoxatin (CAS: 135529-30-5) Product ID: BLK-1080 CAS 135529-30-5 Mechanism Iron chelator Primary Target Ferric iron (Fe3+) Pathway Ergosterol biosynthesis; Iron chelation
Structure
CAS	135529-30-5
Molecular Formula	C15H21NO3
Molecular Weight	263.33
Price	1mg: USD 120.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
Source Organism	Albophoma yamanashiensis.
Summary	Pyridoxatin is a fungal N-hydroxypyridone metabolite with iron-chelating and antifungal activity.
Details	Pyridoxatin is a hydroxamate-containing fungal secondary metabolite first identified as an inducer of erythropoietin gene expression in human cells. Structurally classified as an N-hydroxypyridone, pyridoxatin functions as an iron(III)-chelating agent and exhibits antioxidant properties under iron-dependent oxidative stress conditions. Mechanistic studies demonstrated that pyridoxatin inhibits ergosterol biosynthesis in Candida species, leading to antifungal activity independent of efflux pump mechanisms. Recent phenotypic screening studies further identified pyridoxatin as a promising lead compound against drug-resistant Acinetobacter baumannii.
Browse Related	Mechanism Iron chelator Open full index Primary Target Ferric iron (Fe3+) Open full index Pathway Ergosterol biosynthesis; Iron chelation Open full index Chemical Class Hydroxamate alkaloid Open full index
Mechanism	Iron chelator
Primary Target	Ferric iron (Fe3+)
Pathway	Ergosterol biosynthesis; Iron chelation
Chemical Class	Hydroxamate alkaloid
Discovery Year	1998
Keywords	n-hydroxypyridone metabolite iron chelator ergosterol biosynthesis inhibitor antifungal compound hydroxamate natural product fungal secondary metabolite
References	Kato et al., J Nat Prod, 1998 DOI: 10.1021/np980450t Li et al., Biochim Biophys Acta, 2015 DOI: 10.1016/j.bbagen.2015.05.005 Carvalho et al., Biometals, 2019 DOI: 10.1007/s10534-019-00202-7 Silva et al., Phytochem Lett, 2023 DOI: 10.1016/j.phytol.2023.04.002 Wu et al., Mar Drugs, 2014 DOI: 10.3390/md12031208
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Pyridoxatin (CAS: 135529-30-5)