Name: Quinolactacin A
Brand: Biolinks K.K.
SKU: BLK-1140

For Research Use Only. Not for human or veterinary use.

Quinolactacin A Product ID: BLK-1140 Mechanism TNF-alpha production inhibitor Primary Target Tumor necrosis factor alpha (TNF-α) Pathway LPS-induced TNF signaling pathway
Structure
Molecular Formula	C16H18N2O2
Molecular Weight	270.33
Price	1mg: USD 120.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
Source Organism	Penicillium citrinum.
Summary	Quinolactacin A is a fungal 4-quinolone metabolite that inhibits TNF production.
Details	Quinolactacin A is a secondary metabolite produced by Penicillium species and structurally classified as an N-methyl-4-quinolone conjugated with a γ-lactam moiety. It was originally identified as a potent inhibitor of tumor necrosis factor (TNF)-α production in lipopolysaccharide-stimulated murine macrophages. Isotope-labeling studies clarified its biosynthetic origin from acetate, anthranilate, isoleucine, and methionine precursors. Subsequent heterologous expression and enzymatic reconstitution revealed a concise nonribosomal peptide synthetase (NRPS)-dependent pathway responsible for quinolactacin assembly.
Browse Related	Mechanism TNF-alpha production inhibitor Open full index Primary Target Tumor necrosis factor alpha (TNF-α) Open full index Pathway LPS-induced TNF signaling pathway Open full index Chemical Class 4-Quinolone γ-lactam Open full index
Mechanism	TNF-alpha production inhibitor
Primary Target	Tumor necrosis factor alpha (TNF-α)
Pathway	LPS-induced TNF signaling pathway
Chemical Class	4-Quinolone γ-lactam
Discovery Year	2000
Keywords	tnf production inhibitor 4-quinolone natural product lipopolysaccharide response inhibitor penicillium metabolite nrps-derived metabolite anti-inflammatory research tool
References	Kobayashi et al., J Antibiot, 2000 DOI: 10.7164/antibiotics.53.1247 Kobayashi et al., J Antibiot, 2006 DOI: 10.1038/ja.2006.59 Ye et al., Org Lett, 2020 DOI: 10.1021/acs.orglett.0c02426
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Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF 🧪 Certificate of Manufacture (CofM) – Download HTML
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.