Name: Rasfonin
Brand: Biolinks K.K.
SKU: BLK-1330

For Research Use Only. Not for human or veterinary use.

Rasfonin (CAS: 303156-68-5) Product ID: BLK-1330 CAS 303156-68-5 Mechanism KRAS signaling inhibitor Primary Target KRAS Pathway Ras/MAPK signaling pathway
Structure
CAS	303156-68-5
Molecular Formula	C25H38O6
Molecular Weight	434.57
Price	1mg: USD 290.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
NMR Data	1H NMR (CDCl3, 500 MHz) [View]
Source Organism	Trichurus sp.
Summary	Rasfonin is a fungal 2-pyrone metabolite with immunomodulatory and anticancer activity.
Details	Rasfonin is a fungal secondary metabolite first identified as an immunosuppressive compound and later recognized as an inhibitor of KRAS-dependent cancer cell growth. It suppresses Ras/MAPK signaling by reducing Sos1 expression, leading to decreased Ras activation and downstream Raf/MEK/ERK phosphorylation. Rasfonin induces reactive oxygen species generation, activates JNK signaling, and promotes autophagy and caspase-dependent apoptosis. In vivo studies demonstrated inhibition of KRAS-mutant tumor growth.
Browse Related	Mechanism KRAS signaling inhibitor Open full index Primary Target KRAS Open full index Pathway Ras/MAPK signaling pathway Open full index Chemical Class 2-Pyrone polyketide Open full index
Mechanism	KRAS signaling inhibitor
Primary Target	KRAS
Pathway	Ras/MAPK signaling pathway
Chemical Class	2-Pyrone polyketide
Discovery Year	2005
Keywords	ras mapk pathway modulator 2-pyrone derivative autophagy inducer ros activator fungal polyketide apoptosis research compound
References	Kimura et al., Chem Pharm Bull, 2005 DOI: 10.1248/cpb.53.923 Liu et al., Cell Death Dis, 2014 DOI: 10.1038/cddis.2014.213 Zhang et al., Autophagy, 2016 DOI: 10.1080/21501203.2016.1170073 Wang et al., J South Med Univ, 2019 DOI: 10.19723/j.issn.1671-167X.2019.02.006 Hoffmeister et al., Fungal Biol Biotechnol, 2023 DOI: 10.1186/s40694-023-00158-x
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Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF 🧪 Certificate of Manufacture (CofM) – Download HTML
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.
Representative NMR Data 1H NMR (CDCl3, 500 MHz) Representative spectral data. Actual batch data may vary.

Rasfonin (CAS: 303156-68-5)