Terpendole C (CAS: 156967-65-6)

Terpendole C is an indole-diterpenoid secondary metabolite originally isolated from Albophoma yamanashiensis as part of a series of ACAT inhibitors termed terpendoles. Among the terpendole analogues, terpendole C displayed the most potent inhibition of acyl-CoA:cholesterol acyltransferase (ACAT) with an IC50 value of 2.1 µM in vitro, implicating suppression of cholesterol esterification. Subsequent studies of related indole diterpenes demonstrated tremorgenic activity in mouse models, with terpendole C inducing significant neurotoxic signs. Additional isolation from nematophagous and endophytic fungi confirmed its occurrence across fungal taxa. These findings define terpendole C as a bioactive indole-diterpenoid combining lipid-metabolism inhibition with tremorgenic neurotoxicity.