Name: Thailandolide B
Brand: Biolinks K.K.
SKU: BLK-1120

For Research Use Only. Not for human or veterinary use.

Thailandolide B (CAS: 944726-62-9) Product ID: BLK-1120 CAS 944726-62-9 Mechanism Merodrimane antimicrobial Primary Target Not identified Pathway Meroterpenoid biosynthesis pathway
Structure
CAS	944726-62-9
Molecular Formula	C27H32O8
Molecular Weight	484.55
Price	1mg: USD 170.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
NMR Data	1H NMR (DMSO-d6, 500 MHz) [View]
Source Organism	Penicillium sp.
Summary	Thailandolide B is a merodrimane-type meroterpenoid evaluated for antimicrobial activity.
Details	Thailandolide B is a merodrimane-type meroterpenoid isolated from Talaromyces thailandiasis and structurally related species such as Talaromyces amestolkiae. Its structure was elucidated by spectroscopic analyses and confirmed by X-ray crystallography in related analogues. Additional configurational assignments were supported by TDDFT-ECD and ORD calculations in subsequent studies of ent-thailandolide B. Although thailandolide B and related metabolites were evaluated for antimicrobial activity against bacteria and fungi, no specific molecular target or defined mechanism of action has been reported. Thus, thailandolide B is currently characterized primarily as a structurally defined fungal meroterpenoid with screened antimicrobial properties.
Browse Related	Mechanism Merodrimane antimicrobial Open full index Primary Target Not identified Open full index Pathway Meroterpenoid biosynthesis pathway Open full index Chemical Class Merodrimane meroterpenoid Open full index
Mechanism	Merodrimane antimicrobial
Primary Target	Not identified
Pathway	Meroterpenoid biosynthesis pathway
Chemical Class	Merodrimane meroterpenoid
Discovery Year	2007
Keywords	merodrimane meroterpenoid antimicrobial screening compound talaromyces metabolite freshwater fungus metabolite polyketide-terpenoid hybrid secondary metabolite research scaffold
References	Schneider et al., J Nat Prod, 2007 (isolation and structural elucidation of thailandolides A and B) DOI: 10.1021/np0680578 Harned et al., Tetrahedron Lett, 2021 (ent-thailandolide B; structural analysis; antimicrobial evaluation) DOI: 10.1016/j.tetlet.2021.153067
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.
Representative NMR Data 1H NMR (DMSO-d6, 500 MHz) Representative spectral data. Actual batch data may vary.

Thailandolide B (CAS: 944726-62-9)