Name: Aurodox
Brand: Biolinks K.K.
SKU: BLK-0340

For Research Use Only. Not for human or veterinary use.

Aurodox (CAS: 12704-90-4) Product ID: BLK-0340 CAS 12704-90-4 Mechanism EF-Tu inhibitor Primary Target Elongation factor Tu (EF-Tu); Type III secretion system components Pathway Bacterial protein synthesis; Virulence regulation
Structure
CAS	12704-90-4
Molecular Formula	C44H62N2O12
Molecular Weight	810.99
Price	1mg: USD 140.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Synonyms	Efrotomycin;Antibiotic X-5108
Purity	>95% [View LC/UV Data]
NMR Data	1H NMR (CD3OD, 500 MHz) [View]
Source Organism	Streptomyces sp.
Summary	Aurodox is a type III secretion system inhibitor with anti-virulence activity against Gram-negative pathogens.
Details	Aurodox is a linear polyketide natural product produced by Streptomyces goldiniensis and structurally related to kirromycin. It inhibits bacterial type III secretion systems (T3SS) in Gram-negative pathogens including EHEC, Salmonella, and Yersinia, while also targeting elongation factor EF-Tu. By suppressing virulence rather than bacterial growth, aurodox represents a promising anti-virulence strategy for antimicrobial resistance research.
Browse Related	Mechanism EF-Tu inhibitor Open full index Primary Target Elongation factor Tu (EF-Tu); Type III secretion system components Open full index Pathway Bacterial protein synthesis; Virulence regulation Open full index Chemical Class Elfamycin polyketide Open full index
Mechanism	EF-Tu inhibitor
Primary Target	Elongation factor Tu (EF-Tu); Type III secretion system components
Pathway	Bacterial protein synthesis; Virulence regulation
Chemical Class	Elfamycin polyketide
Discovery Year	1977
Keywords	type iii secretion system inhibitor ef-tu inhibitor anti-virulence compound polyketide antibiotic elfamycin class streptomyces natural product bacterial pathogenicity research tool
References	Zhu et al., Appl Environ Microbiol, 2022 DOI: 10.1128/aem.00692-22 Wallace et al., Open Biol, 2024 DOI: 10.1098/rsob.240240 Kinoshita et al., J Antibiot, 1977 DOI: 10.7164/antibiotics.30.244
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Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF 🧪 Certificate of Manufacture (CofM) – Download HTML
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.
Representative NMR Data 1H NMR (CD3OD, 500 MHz) Representative spectral data. Actual batch data may vary.

Aurodox (CAS: 12704-90-4)