Name: Prodigiosin
Brand: Biolinks K.K.
SKU: BLK-0560

For Research Use Only. Not for human or veterinary use.

Prodigiosin (CAS: 82-89-3) Product ID: BLK-0560 CAS 82-89-3 Mechanism PP2A activator Primary Target Protein phosphatase 2A (PP2A); Akt Pathway Apoptosis pathway; PI3K/AKT signaling pathway
Structure
CAS	82-89-3
Molecular Formula	C20H25N3O
Molecular Weight	323.44
Price	1mg: USD 190.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Synonyms	Prodiginine
Purity	>95% [View LC/UV Data]
Source Organism	ganma-Proteobacterium hahella.
Summary	Prodigiosin is a red bacterial tripyrrole alkaloid with anticancer and antimicrobial activities.
Details	Prodigiosin is a red tripyrrole alkaloid pigment originally isolated from Serratia marcescens and a prototypical member of the prodiginine family. Biosynthetically formed by coupling of methoxybipyrrolecarboxaldehyde and a monopyrrole unit, it exhibits broad biological activities including antibacterial, antifungal, antimalarial, and anticancer effects. Mechanistically, prodigiosin induces apoptosis in cancer cells by activating PP2A and suppressing Akt signaling, leading to p53/p21 upregulation and cell-cycle arrest. Additional studies highlight its immunomodulatory properties and ability to inhibit biofilm formation. Prodigiosin therefore serves as a multifunctional natural product scaffold for oncology, infection, and chemical biology research.
Browse Related	Mechanism PP2A activator Open full index Primary Target Protein phosphatase 2A (PP2A); Akt Open full index Pathway Apoptosis pathway; PI3K/AKT signaling pathway Open full index Chemical Class Tripyrrole alkaloid (prodiginine) Open full index
Mechanism	PP2A activator
Primary Target	Protein phosphatase 2A (PP2A); Akt
Pathway	Apoptosis pathway; PI3K/AKT signaling pathway
Chemical Class	Tripyrrole alkaloid (prodiginine)
Discovery Year	1963
Keywords	tripyrrole alkaloid pp2a activator akt pathway inhibitor apoptosis inducer serratia metabolite anticancer natural product
References	Blizzard et al., J Bacteriol, 1963 DOI: 10.1128/jb.85.5.1136-1140.1963 Gerber, Crit Rev Microbiol, 1975 DOI: 10.3109/10408417509108758 Pérez-Tomás et al., J Enzyme Inhib Med Chem, 2022 DOI: 10.1080/21655979.2022.2084498 Darshan & Manonmani, Drug Discov Today, 2020 DOI: 10.1016/j.drudis.2020.03.017 Wang et al., Sci Rep, 2022 DOI: 10.1038/s41598-022-23186-w Sharma et al., ACS Appl Bio Mater, 2022 DOI: 10.1021/acsabm.1c01187
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Prodigiosin (CAS: 82-89-3)