Aranorosin (CAS: 117184-53-9)

Aranorosin is a novel antibiotic isolated from the fermentation broth of Pseudoarachniotus roseus. Structurally, it contains a unique 1-oxaspiro[4,5]decane ring system. Initially characterized for its antifungal activity, aranorosin was later identified as an inhibitor of Bcl-2-regulated anti-apoptotic functions. It promotes mitochondrial outer membrane permeabilization, induces loss of mitochondrial membrane potential, activates caspase-9, and enhances apoptosis in Bcl-2-overexpressing cells. These findings position aranorosin as a natural product scaffold of interest for apoptosis-targeted anticancer research.