Name: Boromycin
Brand: Biolinks K.K.
SKU: BLK-1280

For Research Use Only. Not for human or veterinary use.

Boromycin (CAS: 34524-20-4) Product ID: BLK-1280 CAS 34524-20-4 Mechanism Polyether ionophore Primary Target Parasite membrane ion homeostasis components Pathway Parasite proliferation; Membrane ion homeostasis
Structure
CAS	34524-20-4
Molecular Formula	C45H74BNO15
Molecular Weight	879.9
Price	1mg: USD 300.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
NMR Data	1H NMR (CD3OD, 500 MHz) [View]
Source Organism	Streptomyces sp.
Summary	Boromycin is a boron-containing macrolide with potent nanomolar antiparasitic activity.
Details	Boromycin is a boron-containing polyether macrolide antibiotic produced by Streptomyces antibioticus. It exhibits potent nanomolar activity against multiple apicomplexan parasites including Plasmodium falciparum, Toxoplasma gondii, and Cryptosporidium parvum, with rapid killing of asexual and sexual blood stages of malaria parasites. Boromycin also shows antiviral activity against HIV-1 and displays ionophore-like effects on membrane function. Its broad antiparasitic profile and rapid onset of action make it a promising candidate for antiparasitic drug development.
Browse Related	Mechanism Polyether ionophore Open full index Primary Target Parasite membrane ion homeostasis components Open full index Pathway Parasite proliferation; Membrane ion homeostasis Open full index Chemical Class Boron-containing polyether macrolide Open full index
Mechanism	Polyether ionophore
Primary Target	Parasite membrane ion homeostasis components
Pathway	Parasite proliferation; Membrane ion homeostasis
Chemical Class	Boron-containing polyether macrolide
Discovery Year	1967
Keywords	boron-containing macrolide polyether antibiotic ionophore-like compound antiparasitic agent antimalarial compound anti-toxoplasma activity anti-cryptosporidium activity microbial natural product
References	Hernández et al., Antimicrob Agents Chemother, 2020 DOI: 10.1128/AAC.01278-20 Breitbach et al., Front Cell Infect Microbiol, 2021 DOI: 10.3389/fcimb.2021.802294 Kohno et al., Biosci Biotechnol Biochem, 1996 DOI: 10.1271/bbb.60.1036
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Representative NMR Data 1H NMR (CD3OD, 500 MHz) Representative spectral data. Actual batch data may vary.

Boromycin (CAS: 34524-20-4)